Enterococcus faecalis

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound.

4aα,7α,7aα-Nepetalactone exhibits antibacterial properties, effectively inhibiting the growth of Escherichia coli (E. coli), Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, and Enterococcus faecalis.

Wychimicin C, a spirotetronate polyketide isolated from the rare actinomycete, Actinocrispum wychmicini strain MI503-AF4, demonstrates potent antibacterial efficacy. Specifically, it exhibits significant activity against methicillin-resistant Staphylococcus aureus (IC 50 =0.125-0.5 μg mL) and Enterococcus faecalis faecium (IC 50 =0.125-0.25 μg mL) [1] [2].

Wychimicin A, a spirotetronate polyketide isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4, exhibits potent antibacterial activity. Specifically, it demonstrates efficacy against methicillin-resistant Staphylococcus aureus (IC 50 = 0.125-0.5 μg mL) and Enterococcus faecalis faecium (IC 50 = 0.125-0.25 μg mL) [1] [2].

14-Deoxycoleon U has anti-termitic activity, it is highly active against both wood-decay fungi. 14-Deoxycoleon U shows antibacterial activity against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and

Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs

Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with the IC50value of 23.3 microM. Neogrifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, the MIC values of 20 and 0.5 microg mL, respectively.

Gypsogenic acid, a triterpenic acid isolated from Miconia stenostachya, exhibits antibacterial and antitrypanosomal activities. This compound demonstrates minimum inhibitory concentrations (MICs) ranging from 50-200 μg mL against oral bacterial pathogens including Enterococcus faecalis, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus spp., and Streptococcus sobrinus. Additionally, gypsogenic acid can induce the lysis of Trypanosoma cruzi in isolated mouse blood, with an IC50 value of 56.6 μM.